Bristol Myers Squibb Genomics Research Associate in Hopewell, New Jersey
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.
Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.
The Clinical Genetics and Genomics team is seeking an innovative and highly motivated scientist to join our world-class team. The selected scientist will be responsible for genomics biomarker assay development, optimization, validation and execution of biomarker analysis for BMS translational research and clinical programs. The scientist must have a strong background in genomics as well as experience with and understanding of immunology or immunoscience related disciplines.
Assay design and development: Understand program biology requirements working with the biomarker and program leads and help develop the genomics biomarker strategy and execution plan working with the technology leads.
Design, develop, optimize genomics and genetics biomarker assays and develop and execute the validation of these assays for clinical trial assays.
Key assay profiles likely to include NGS or qPCR based gene expression systems, genotyping or variant analysis utilizing NGS or qPCR or other methodologies.
This is a lab based position with a significant opportunity to interface with program teams to understand program requirements and background, assay and analysis requirements, analysis timelines, analysis needs
A significant part of time will be spent assisting development and analysis of validation data. A strong understanding of assay validation and fit for purpose assay validation requirements will be essential.
In case of outsourced studies, the incumbent will provide oversight of assay development and execution of sample analysis at the vendor.
Help to draft experimental plans, validation reports, work instructions, technology transfer documents, study summaries and SOPs.
Actively participate in internal/external collaboration, portfolio management groups and clinical study and biomarker execution teams.
Providing subject matter expertise for clinical and program teams as required.
Accurate record keeping of experiments and procedures
Observe technology developments and innovate on new methodology per team requirements.
Work closely with data analysis teams as well as sample management and clinical operation teams on programs.
Experience in genomics based studies of immunooncology, oncology immunology or related fields.
Masters Degree with 5 yrs experience or Phd with 2 years experience with relevant work experience.
Experience in clinical assay development for gene expression profiling assets.
Understanding of fit for purpose genomics assay validation principles for clinical assays.
Experience with genomics (NGS, qPCR) assay development, validation, troubleshooting, and reviewing of run QC data.
In-depth knowledge of different genomics platforms and technologies (for the clinic).
Familiarity with NGS and qPCR data analysis and QC to develop a strong interaction with the data analysis team.
Technical expertise with molecular technologies, including but not limited to: NGs, single cell NGS, PCR, quantitative real-time PCR, digital PCR, NanoString,and other relevant methodologies.
Must have strong organizational and interpersonal skills with excellent leadership skills.
Must be self-motivated, with demonstrated ability to work independently and learn quickly.
Must be goal oriented and focused on completing work on time.
Thrive in a highly interactive, fast-paced and dynamic team environment.
Must be able to quickly adapt to changing priorities and work well in fast pace environment and under pressure.
Ability to mentor others on technical operating systems
Ability to independently review and understand project proposals/plans
Ability to work in a matrixed team in a high pressure environment.
Excellent communication skills with ability to serve as key contact for program teams.
Must have excellent organization and record keeping skills
Must be highly resourceful and work across matrix teams.
Previous industry experience is a plus
Previous experience in a clinical laboratory setting is a plus
Bioinformatics and data interpretation fluency and ability to engage with Bioinformatics team to appropriately QC and query datasets.
Understanding of design of experiments, randomization of samples for clinical analysis.
Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.