Bristol Myers Squibb Research Associate in Cambridge, Massachusetts
The Senior Research Associate (title and grade will depend upon experience and education) will join the Integrated Oncology Discovery Research team at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immune biology.
The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in the oncology, immunology, immuno-oncology, protein engineering/antibody development and medicinal chemistry groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.
· A B.S. with a minimum of 5 years of experience, or an M.S. with a minimum of 3 years of academic/industrial experience with strong scientific knowledge and research experience in cancer biology/cellular and molecular biology is required.
· Demonstrated independence in experimental design, execution, data analysis and troubleshooting is required.
· Knowledge of preclinical drug development including knowledge of designing assays and flowcharts to identify and optimize drug candidates is required.
· Hands on experience with a wide range of in-vitro cellular and biochemical assays, including cell culture, western blotting, immunoprecipitation, ELISAs (MSD), reporter assays, siRNA/shRNA knockdown, CRISPR-mediated genome editing, qPCR, cloning, lentivirus generation and transduction is required.
· Experience with in vivo/ex vivo pharmacology, including rodent handling and common procedures including tissue processing is desired. Working knowledge of in-vivo PK, PD and efficacy studies is desirable.
· Experience in data mining through use of desktop tools/interfaces and public databases (e.g., UCSC genome Browser, CBIO, GTex, Oncoland etc) is highly desirable.
· Proficiency in utilizing software such as Graph Pad, Microsoft office etc. for data analysis and figure generation is required.
· Ability to mentor more junior scientists and ease in sharing expertise with colleagues on best practices in the laboratory would be highly valued.
· Attention to detail with excellent organizational and record keeping skills is a requirement.
· Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.
· This position is located in Cambridge, MA. There will be less than 10% travel.
Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.